Endocrine Abstracts

Congenital adrenal hyperplasia (CAH) owing to 21 hydroxylase deficiency (21OHD) is an inherited autosomal disorder characterized by diminished glucocorticoid and aldosteron biosynthesis. Partial 21OHD leads to the classical simple virilizing form, characterized by prenatal virilization of external genitalia in female fetuses without salt wasting. Ambiguous genitalia in a genetically female infant is frequently due to CAH. The uncertainty about the sex of a newborn is often inc...

In new classification of autoimmune polyendocrine syndromes (APS), APS-3 has defined as combination of autoimmune thyroid disease and other autoimmune disease except hypoparathyroidism and Addison’s disease. The present report describes a patient with APS-3 and pseudomalapsorbtion of levothyroxine (LT4). Twenty-three year old woman was referred to our center with hypothyroidism due to Hashimoto’s thyroiditis (HT) despite the usage of high dose LT4 treatment. HT was d...

Introduction: Hand-Foot-Uterus Syndrome (HFUS) is a rare genetic condition. It is characterized by abnormalities of the hand, foot, reproductive tract, and urinary tract. There are also wrist- and ankle-bone fusions, very small feet, short great toes, urinary-tract abnormalities, duplications of the reproductive tract in women, urethral openings on the underside of the penis in men, and curved penis. The genetic associations of HFUS is not fully understood. It seems that the m...

Introduction: U-300 insulin glargine has been used as a concentrated form of glargine. Skin and subcutaneous tissue disorders (eg, rash, pruritus, and urticaria) have been reported with insulin glargine. But to our knowledge, maculopapular rash has not been reported with use of U-300 insulin glargine. We present a patient with type 1 diabetes mellitus(DM) developing maculopapular rash after initiation of U-300 glargine insulin.Case Report: 37 year-old fe...

The syndrome of inappropriate secretion of antidiuretic hormone (SIADH) is a disorder of impaired water excretion caused by inability to suppress secretion of antidiuretic hormone. The therapy of SIADH varies with severity of hyponatremia and presence or absence of symptoms. Non-peptide vasopressin receptor antagonists (vaptans) are effective at increasing sodium in euvolemic and hypervolemic states and appear safe. We aimed to evaluate the efficacy of tolvaptan in euvolemic h...

İntroduction: Polycystic ovary syndrome (PCOS) is associated with risk of cardiovascular disease (CVD). Endocan is potential immunoinflammatory and endothelial dysfunction marker that may be linked to CVD. This study aimed to evaluate the risk of CVD in PCOS patients and to identify the novel biomarker for CVD risk.Material and methods: We analyzed 52 premenopausal women with PCOS and 59 healthy controls. Clinical, biochemical parameters and endoca...

Aim: Gestational diabetes mellitus (GDM) is a disorder which is described as impaired glucose tolerance which firstly occurs first time during pregnancy. We aimed to evaluate the tear function tests such as Schirmer, tear break-up time (TBUT), tear film osmolarity (TFO), and ocular surface disease index (OSDI) score in pregnant with GDM.Methods: Pregnant women with GDM and healthy pregnant who were matched in both age and gestational age were enrolled in...

Aim: The prevalence of overweight and obesity is increasing and becoming a global health problem. Obesity is the cause of increased cardiovascular morbidity and mortality and psychosocial problems. There are several reports which mentioning the unfavourable effects of aggressive weight loss regimes on the immune system. This study was designed to search for the effect of a straightforward, controlled and permanent weight loss program on the immune system.<p class="abstext"...

The efficacy of peritoneal dialysis (PD) is closely related to the status of the peritoneum. Long-term PD leads to structural and functional changes in the peritoneum and affects dialysis adequacy. Also high-glucose content of dialysate accelerates peritoneal fibrosis. It is reported that ultrasonography (USG) reflects parietal peritoneal membrane thickness and PD duration is related with peritoneal thickness. This study aimed to evaluate peritoneal thickness with USG in PD pa...

Background and aim: The risk for breast cancer in patients with thyroid cancer has been investigated in previous studies, and has been found to be increased. In this study we, therefore present retrospective analysis of the patients with differentiated thyroid carcinoma in respect to breast cancer and family history for breast cancer.Methods: We conducted a retrospective study involving 455 patients with a diagnosis of differentiated thyroid carcinoma be...